针对希斯3变体表观遗传景观和抑制性免疫检查点:儿童脑瘤治疗的选择
Sarasa Meenakshi1, Krushna Ch Maharana2, Lokesh Nama2
1Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research, Hajipur, Vaishali- 844102, Bihar, India.
Current neuropharmacology
|August 22, 2023
概括
针对CTLA-4和PD-1/PD-L1等免疫检查点的新型免疫疗法,以及表观遗传改变,通过克服治疗耐药性,为治疗儿科脑瘤 (PBT) 提供了新的希望.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 儿童大脑瘤 (PBTs) 在使用传统疗法时的生存率很低.
- 现有的PBT治疗方法往往具有毒性副作用和有限的疗效.
- 免疫逃避机制,包括共抑制性免疫检查点和表观遗传变化,在PBT中至关重要,但尚未得到充分研究.
研究的目的:
- 审查PBT中共抑制性免疫检查点蛋白和基因组表观遗传变化的作用.
- 讨论PBT中这些目标的机制,信号通路和当前的研究状态.
- 探索儿童脑瘤治疗中免疫治疗的未来机会.
主要方法:
- 对PBT中的共抑制性免疫检查点 (CTLA-4,PD-1/PD-L1,CD200,IDO) 和基因组修饰的文献综述.
- 对表观遗传机制的分析,包括乙化,甲基化,酸化,相化,聚 (ADP) - 核糖化和无处不在化.
- 审查目前关于PBT免疫疗法的临床和临床前研究.
主要成果:
- 同抑制性免疫检查点和基因组表观遗传变化在PBT免疫逃避中起着重要作用.
- 关键检查点如CTLA-4,PD-1/PD-L1,CD200和IDO都与PBT进展有关.
- 基因组蛋白修饰是已知的表观遗传调节剂,具有潜在的治疗意义.
结论:
- 针对免疫检查点和表观遗传改变为新型PBT免疫疗法提供了有希望的途径.
- 对这些机制的进一步研究可能会导致对PBT的更有效,更少毒性治疗策略.
- 涉及免疫调节和表观遗传向的组合疗法可能会改善儿科脑瘤的结果.
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