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Updated: Jul 18, 2025

Collecting Variable-concentration Isothermal Titration Calorimetry Datasets in Order to Determine Binding Mechanisms
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Collecting Variable-concentration Isothermal Titration Calorimetry Datasets in Order to Determine Binding Mechanisms

Published on: April 7, 2011

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导出蛋白质结合校正的化学度用于体外试验.

Aditya R Kolli1

  • 1PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland.

Clinical and translational science
|August 22, 2023
PubMed
概括

准确的体外试验需要考虑蛋白质结合. 这项研究开发了计算校正化学度的模型,确保了药物开发和毒理学方面的生理学相关结果.

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Physiological Pharmacokinetic Models: Assumption with Protein Binding

Physiological models with protein binding in pharmacokinetics offer a sophisticated approach to understanding drug disposition. These models consider drug-protein interactions, enabling them to effectively predict drug concentrations in different organs and tissues. This precision aids in accurate drug dosing, providing a significant advantage over conventional models. A key process within these models is equilibration, which ensures that drug concentrations achieve a steady state within the...
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