在OSAHS患者中hs-CRP,VCAM-1,LEP水平和血压变化之间的相关性
Dengxiang Wu1, Hongxiao Li1, Jiangqing Yu1
1Department of Respiratory and Critical Care Medicine, The Second People's Hospital of Jingdezhen, Jingdezhen 333000, Jiangxi Province, China. yintao3167006707@163.com.
Cellular and molecular biology (Noisy-le-Grand, France)
|August 22, 2023
概括
高敏感性C反应蛋白 (hs-CRP),VCAM-1和瘦素 (LEP) 水平在阻塞性睡眠呼吸暂停-呼吸暂停综合征 (OSAHS) 患者中升高. 这些标记与增加的血压变异性相关,有助于OSAHS严重性评估.
科学领域:
- 心血管生理学心血管生理学
- 睡眠医学 睡眠医学
- 生物标志物 生物标志物
背景情况:
- 阻塞性睡眠呼吸暂停-呼吸暂停综合征 (OSAHS) 与心血管并发症有关.
- 炎症标志物和内皮功能障碍可能在OSAHS的发病过程中发挥作用.
- 血压变化 (BPV) 是心血管风险的一个指标.
研究的目的:
- 在OSAHS患者中研究高灵敏度C反应蛋白 (hs-CRP),VCAM-1,瘦素 (LEP) 和血压变化 (BPV) 之间的关系.
- 评估这些生物标志物是否可以作为OSAHS严重程度的指标.
主要方法:
- 92名OSAHS患者根据呼吸暂停-呼吸暂停指数 (AHI) 被分为轻度,中度和重度组.
- 测量了hs-CRP,VCAM-1和LEP的血清水平.
- 评估了血压的变化 (白天和夜间的心压和腹压血压).
- 用皮尔森相关性分析来确定生物标志物和BPV之间的关系.
主要成果:
- 与对照组相比,OSAHS患者的AHI显著更高.
- 血清hs-CRP,VCAM-1和LEP水平,以及白天和夜间血压变化 (dSBP,dDBP,nSBP,nDBP),随着OSAHS严重程度的增加而升高.
- 夜间缩血压 (nSBP) 与hs-CRP,VCAM-1和LEP水平有显著的正相关性.
结论:
- 与健康个体相比,在OSAHS患者中存在hs-CRP,VCAM-1和LEP的血清水平升高.
- 这些生物标志物与血压变化增加有显著的相关性,特别是在夜间.
- hs-CRP,VCAM-1和LEP显示出评估OSAHS严重性的重要指标的潜力.
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