基因预测了肠道微生物群和不孕不育之间的因果关系:双向门德尔随机化分析在预测,预防和个性化医学的框架内
Yujia Xi1,2, Chenwei Zhang2, Yiqian Feng3
1Department of Urology, The Second Hospital of Shanxi Medical University, 382 Wuyi Road, Taiyuan, 030001 Shanxi China.
The EPMA journal
|August 22, 2023
概括
这项研究揭示了特定肠道细菌与不孕症之间的因果关系. 监测肠道微生物群可能有助于早期发现和个性化预防不孕症.
科学领域:
- 微生物组研究的研究.
- 生殖健康 生殖健康
- 遗传学 遗传学 是一个
背景情况:
- 报道了肠道微生物群和不孕症之间的关联,但缺乏因果关系证据.
- 预测,预防和个性化医学 (PPPM) 为新型不孕症干预提供了一个框架.
研究的目的:
- 探索肠道微生物群和不孕不育之间的因果关系.
- 在PPPM框架内确定用于早期不孕症监测和预防的特定肠道细菌.
主要方法:
- 利用孟德尔的随机化 (MR) 分析对来自18340个人的肠道微生物群GWAS数据.
- 包括来自FinnGen联盟的女性不孕症 (6481例,68969对照) 和男性不孕症 (680例,72799对照) 数据.
- 使用IVW,MR-Egger,加权中位数,Cochran Q测试,MR-PRESSO和留出一个方法进行了灵敏度分析.
主要成果:
- 在特定的肠道细菌和男性不孕症之间确定了因果关系,包括Eubacterum oxidoreducens,乳球菌,Eubacterum ventriosum,Eubacterum rectale和Ruminococcaceae NK4A214.
- 在遗传预测的肠道细菌 (Eubacterium ventriosum,Holdemania,Lactococcus,Ruminococcaceae NK4A214,Ruminococcus torques,Faecalibacterium) 和女性不孕症之间发现了联系.
- 灵敏度分析证实没有显著的异质性或质性.
结论:
- 提供了某些肠道微生物群与男性和女性不孕不育之间的因果关系的证据.
- 这些发现支持监测和调节肠道微生物群,以进行个性化的不孕症预防和治疗.
- 便微生物群分析可以增强预防性和个性化的不孕症管理策略.
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