系统性免疫炎症指数与非酒精性脂肪性肝病的关联:基于人口的横截面研究
1Department of Gastroenterology, Jinshan Branch of Shanghai Sixth People's Hospital, Shanghai, 201500, People's Republic of China.
Risk management and healthcare policy
|August 22, 2023
概括
系统性免疫炎症 (SII) 指数显示,美国普通人群中与非酒精性脂肪肝 (NAFLD) 风险之间存在U形关系. 监测动态SII指数变化对于了解NAFLD风险至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 非酒精性脂肪肝 (NAFLD) 是一个日益严重的公共卫生问题.
- 系统性免疫炎症指数 (SII) 是一种反映系统性炎症的新型生物标志物.
研究的目的:
- 调查SII指数与美国普通人口中NAFLD风险之间的关联.
- 探索SII指数和肝纤维化得分之间的关系.
主要方法:
- 使用国家健康和营养检查调查 (NHANES) 2017-2018年数据进行横截面研究.
- 进行了多变量后勤回归,限制立方线 (RCS) 图形和子组分析.
- 一般化添加模型评估了SII指数与ZJU,BARD和NAFLD纤维化得分的相关性.
主要成果:
- 在四分位数中观察到SII指数和NAFLD风险之间存在U形关联.
- 这种U形相关性在各种人口和临床子组中持续存在.
- SII指数与ZJU指数呈现线性正相关,与NAFLD纤维化得分呈现负相关.
结论:
- 在SII指数和NAFLD风险之间存在显著的U形关系.
- 在SII指数的动态变化需要注意NAFLD风险评估.
- 在NAFLD评估中,SII指数可以作为一个有价值的指标.
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