编程细胞死亡途径作为开发抗流感药物的目标:从最近的发现中吸取教训
Nabarun Chandra Das1, Pritha Chakraborty1, Samapika Nandy2,3
1Integrative Biochemistry & Immunology Laboratory, Department of Animal Science, Kazi Nazrul University, Asansol, India.
Journal of cellular and molecular medicine
|August 22, 2023
概括
淋巴状细菌症仍然是一个全球性的健康挑战. 这项研究探讨了作为药物点的亡,表明天然和合成化合物有效地诱导寄生虫死亡,宿主毒性最小.
科学领域:
- 寄生虫学的寄生虫学
- 药物发现 药物发现 药物发现
- 分子生物学分子生物学
背景情况:
- 尽管有控制计划,但淋巴状细菌病 (LF) 在全球范围内仍然存在,影响人类和牲畜,并导致显著的发病率.
- 现有策略需要针对成年 filarial 线虫的新疗法来实现消除目标.
- 识别有效的药物点对于开发强效抗药剂至关重要.
研究的目的:
- 探索细胞亡作为潜在的治疗向对抗 filarial 线虫.
- 评估自然和合成化合物/纳米配方在诱导寄生虫亡中的有效性.
主要方法:
- 研究了反应性氧物种 (ROS) 在触发 filarial 寄生虫中通过内在和外在途径触发亡的作用.
- 测试了各种天然和合成化合物和纳米配方,以检测它们在 filarial 寄生虫中诱导 apoptotic 死亡的能力.
- 评估这些化合物的对宿主体系统的毒性.
主要成果:
- 细胞亡是 filarial 线虫 (卵细胞,微粒细胞和成年人) 在所有生命阶段的可行目标.
- 几种天然和合成化合物/纳米配方在诱导 filarial 寄生虫的亡死亡方面表现出有效性.
- 测试的化合物对宿主有极小的毒性或没有毒性.
结论:
- 向细胞亡,特别是通过ROS信号传递,是开发新抗流感药物的有希望的策略.
- 天然和合成化合物/纳米配方显示出潜在的有效和安全的治疗药物,用于对抗淋巴性 filariasis.
- 对这些化合物的进一步研究可能会导致新的治疗方法,以消除淋巴状细菌病.
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