罗皮瓦卡因与sufentanil结合在腹部外科手术中的外周麻醉效果
Songfeng Li1, Yong Zhan1, Shaojin Bu1
1Department of Anesthesiology, Fengdu People's Hospital, Chongqing, China.
Pakistan journal of pharmaceutical sciences
|August 22, 2023
概括
与单独使用罗皮瓦卡因相比,罗皮瓦卡因加上sufentanil外周麻醉显著改善了麻醉效果,并减少了腹部手术患者的术后疼痛和不良反应. 这种组合提供了增强的镇静作用和更好的安全性.
科学领域:
- 麻醉学 麻醉学
- 手术麻醉手术麻醉
- 药理学 药理学是指药理学的学科.
背景情况:
- 外周麻醉对于腹部手术至关重要.
- 优化麻醉剂对于患者的治疗结果至关重要.
- 罗皮瓦卡因和苏芬坦尼尔是常用的麻醉剂.
研究的目的:
- 评估ropivacaine与sufentanil结合在腹部外科手术中的外周麻醉的疗效和安全性.
- 为了比较单独的罗皮瓦卡因和罗皮瓦卡因加sufentanil之间的麻醉作用,术后疼痛,镇静水平和不良反应.
主要方法:
- 一项随机对照试验,涉及120名接受腹部手术的患者.
- 患者被分配给单独接受罗皮瓦卡因 (控制) 或罗皮瓦卡因加苏芬坦尼尔 (观察) 进行外周麻醉.
- 麻醉效果,视觉模拟量表 (VAS) 疼痛评分,兰赛镇静量表 (RSS) 评分和不良反应被评估.
主要成果:
- 罗皮瓦卡因加苏芬坦尼尔组显示出显著更高的总麻醉效果 (96.66%vs78.33%,P<0.05).
- 手术后的VAS得分在观察组在4,8,16和24小时 (P<0.05) 显著较低.
- 在观察组中,不良反应的发生率明显较低 (5.00%与30.00%,P<0.05).
结论:
- 罗皮瓦卡因加苏芬坦尼尔外周麻醉在腹部手术中比单独的罗皮瓦卡因更有效.
- 组合疗法导致更好的疼痛控制和镇静.
- 这种组合降低了不良事件的风险,提高了患者的安全.
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