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Updated: Jul 18, 2025

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform
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对于MAFA和MAFB转录因子在调节小岛β细胞身份的特定物种作用

Jeeyeon Cha1, Xin Tong2, Emily M Walker2

  • 1Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

JCI insight
|August 22, 2023
PubMed
概括

转录因子MafA和MAFB对于维持胰腺β细胞在2型糖尿病 (T2D) 中的同一性至关重要. 这些因素的丧失导致激素表达不当,这是功能失调的β细胞的标志.

关键词:
贝塔细胞 贝塔细胞 贝塔细胞细胞生物学 细胞生物学糖尿病 糖尿病 糖尿病内分泌学 在内分泌学.岛屿细胞 岛屿细胞

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