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循环的miR-146a预测了甲状腺眼病中的葡萄糖皮质醇反应

Jacopo Manso^1,2, Simona Censi¹, Cristina Clausi¹

¹Department of Medicine (DIMED), Endocrinology Unit, University of Padua, Padua, Italy.

European thyroid journal

|August 22, 2023

概括

血液中的微RNA-146a (miR-146a) 可以预测甲状腺眼病 (TED) 患者对葡萄糖皮质激素 (GC) 治疗的反应如何. 这一发现可能有助于个性化TED的GC治疗.

科学领域:

眼科医生眼科眼科
内分泌学在内分泌学.
免疫学免疫学免疫学

背景情况:

甲状腺眼病 (TED) 是一种影响眼睛的免疫媒介疾病.
静脉注射葡萄皮质激素 (GC) 是中度至重度活跃TED的主要治疗方法,但反应率各不相同 (50-80%).
在TED中缺乏对GC响应性的预测标记.

研究的目的:

研究miR-146a和miR-21作为预测TED患者GC治疗反应的生物标志物的潜力.
确定与活跃中度至重度TED中GC响应度相关的因素.

主要方法:

一项前性纵向研究包括30名具有活跃中度至重度TED的成年患者,接受标准IV甲基prednisolone.
对GC的反应被定义为24周临床活性得分 (CAS) 或CAS<4/10的降低.
血清循环的microRNAs (miRNAs),包括miR-146a和miR-21,使用实时PCR量化.

主要成果:

显著的77%的患者对GC治疗有反应.
循环中的miR-146a在治疗前的较高水平,以及甲状腺手术史,较高的CAS和较大的亡,预测了GC的响应性.
接收器操作特征 (ROC) 分析表明,miR-146a对GC响应能力具有100%的积极预测值.

结论:

这项研究确定了治疗前循环的miR-146a作为一种新的客观生物标志物,用于预测TED中的GC敏感性.
miR-146a有可能指导临床医生选择适当的GC疗法,避免TED患者的无效治疗.

关键词:

葡萄糖皮质类药物反应的反应葡萄糖皮质类药物敏感性在 miR-146a 里面.据报道,米R-21的发射器是米R-21 这是一个微型RNA.甲状腺眼睛疾病甲状腺眼睛疾病

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