将纳米材料诱导的线粒体功能障碍与化学物质现有的不良结果途径联系起来
Sivakumar Murugadoss1,2, Ivana Vinković Vrček3, Alexandra Schaffert4
1Scientific Direction of Chemical and Physical Health Risks, Sciensano, Brussels, Belgium.
ALTEX
|August 22, 2023
概括
这项研究将线粒体毒性纳入纳米材料 (NM) 的不良结果途径 (AOP). 它确定了适用于NM毒性的现有AOP,突出了对NM物理化学性质和线粒体影响需要更好的数据的需求.
科学领域:
- 毒理学 毒理学 毒理学
- 纳米材料的安全性
- 负面的结果路径
背景情况:
- 不良结果路径 (AOP) 框架对于通过新方法方法来推进毒性测试至关重要.
- 虽然化学品的AOP理论上可以应用于纳米材料 (NM),但它们对NM毒性的整合正在芽.
- 之前的工作确定了与NM分子启动事件 (MIEs) 和关键事件 (KEs) 相关的AOP,揭示了重要的线粒体毒性作用.
研究的目的:
- 为了生成基于假设的AOP,专门针对NM诱导的线粒体毒性.
- 将NM线粒体毒性的现有知识整合到AOP-Wiki中.
- 在AOP-Wiki中确定相关的AOP,以开发NM特定的AOP.
主要方法:
- 系统地将NM诱导的线粒体毒性数据集成到AOP-Wiki中的现有AOP中.
- 文献综述侧重于NM毒性和线粒体MIEs/KEs.
- 分析与肺,肝脏,心血管和神经系统相关的AOP,以确定NM的相关性.
主要成果:
- 在AOP-Wiki中发现,一些现有的AOP适合开发NM相关的AOP,特别是那些涉及线粒体毒性的AOP.
- 在几个与NM相关的AOP中,线粒体毒性被确定为分子和细胞水平的重要因素.
- 一个显著的限制是研究质量差,特别是关于NM的物理化学特征和报告NM相关的线粒体MIEs.
结论:
- NM诱导的线粒体毒性在人类不良结果中发挥着潜在的作用.
- AOP-Wiki包含有用的AOP,可以用于开发NMS的AOP.
- 在研究中改善NM物理化学性质和线粒体影响的报告对于推进NM安全评估至关重要.
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