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红细胞分布宽度与青少年晚期的体重指数相反相关
A Klisic1, I Radoman Vujačić, J Kostadinovic
1Faculty of Medicine, University of Montenegro, Podgorica, Montenegro. aleksandranklisic@gmail.com.
European review for medical and pharmacological sciences
|August 22, 2023
概括
较低的红细胞分布宽度 (RDW) 值预测了青少年更高的体重指数 (BMI). 这一发现表明,RDW可以作为一种有用的生物标志物,用于识别年轻人的超重和肥胖.
科学领域:
- 血液学 血液学 血液学
- 儿科内分泌学 儿科内分泌学
- 公共卫生 公共卫生
背景情况:
- 肥胖是青少年日益严重的健康问题.
- 红细胞 (RBC) 和血小板 (PLT) 指数与青少年晚期肥胖之间的关系仍未得到充分研究.
- 研究这些血液学标记可以为肥胖的预测和管理提供新的见解.
研究的目的:
- 探索RBC和PLT指数与晚年青少年队列中肥胖之间的关联.
- 在这个年龄组中确定超重和肥胖的潜在血液学生物标志物.
主要方法:
- 分析了一组156名年龄在16-19岁的青少年.
- 测量了红细胞和PLT指数,包括血红蛋白 (HGB),血红素 (HCT),平均体质量 (MCV),平均体质血红素 (MCH),平均体质血红素度 (MCHC),红细胞分布宽度 (RDW),平均血小板量 (MPV),血小板量 (PCT) 和血小板分布宽度 (PDW).
- 使用单变量和多变量二进制回归计算和分析了衍生指数和体重指数 (BMI).
主要成果:
- 单变量分析显示了BMI和RDW,PDW,PDW/PCT,MPV和PCT之间的关联.
- 多变量分析确定红细胞分布宽度 (RDW) 是高BMI的唯一独立预测因子 (几率比=0.734,p=0.038).
- 较低的RDW值与青少年晚期的BMI较高显著相关.
结论:
- 减少RDW是青少年BMI增加的独立预测因素.
- RDW提供了一个潜在的低成本,易于测量的生物标志物,用于早期检测年轻人群中的超重和肥胖.
- 进一步的研究可以验证RDW在青少年肥胖查和管理策略中的实用性.
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