沉性大动脉狭窄症的负担:背后有什么?
S Romiti1, M Vinciguerra, M D'Abramo
1Department of Clinical, Internal Medicine, Anaesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy. silvia.romiti@uniroma1.it.
European review for medical and pharmacological sciences
|August 22, 2023
概括
动脉硬化 (CAS) 是一种常见的心血管疾病,没有有效的医学治疗方法. 本综述探讨了CAS的致病性以及这种生长状况的潜在新治疗点.
科学领域:
- 心血管医学 心血管医学
- 病理生理学 病理生理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 动脉狭窄 (CAS) 是西方国家心血管疾病 (CVD) 死亡的主要原因.
- 随着年龄的增长,CAS的患病率会增加,目前的指导方针缺乏预防其发展或减缓其进展的治疗方法.
- 人口老龄化和有限的医疗选择表明,在未来几十年内,CAS病例的数量可能会增加一倍或三倍.
研究的目的:
- 审查CAS的致病性.
- 提供当前病理生理学见解的概述.
- 为了确定CAS的新型潜在治疗点.
主要方法:
- 对现有关于CAS病变发生的研究的文献综述.
- 分析当前的病理生理机制.
- 识别和讨论新兴的治疗策略.
主要成果:
- 详细检查CAS中涉及的复杂生物途径.
- 对大动脉膜化病理生理学的当前知识的综合.
- 突出了未来药物开发的几个有前途的分子标.
结论:
- 酸是一种显著且日益严重的公共卫生问题.
- 了解CAS的致病性对于开发有效的治疗方法至关重要.
- 新的治疗标为管理和潜在地预防CAS进展提供了希望.
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