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通过ERECTA信号通路对女性生殖线发育的表观遗传调节

Youmei Huang¹, Liping Liu², Mengnan Chai¹

¹College of Life Sciences, Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.

The New phytologist

|August 22, 2023

概括

表观遗传因素SWI2/SNF2-RELATED 1 (SWR1) 和SET DOMAIN GROUP 2 (SDG2) 与ERECTA (ER) 途径相互作用,控制植物雌性生殖线的发展. 这种调节可以确保单个细胞在性繁殖过程中经历半变化.

科学领域:

植物生殖生物学植物生殖生物学
表观遗传学和基因调节
分子植物科学分子植物科学

背景情况:

植物的性繁殖依赖于精确的生殖线发育,由巨母细胞 (MMCs) 的半分裂开始.
表观遗传机制与MMC规范有关,但它们在下游生殖系发展中的作用基本上尚不清楚.
了解这些过程对于植物育种和生殖生物学至关重要.

研究的目的:

阐明表观遗传因素和信号通路控制Arabidopsis中雌性生殖线发育的分子机制.
研究表观遗传调节剂与ERECTA (ER) 受体激酶通路之间的遗传相互作用.
确定控制MMC命运决定和介质启动的基因调控网络.

主要方法:

电泳运动移动性转移试验 (EMSA)
西方斑点和免疫光分析分析.
染色体免疫沉与定量PCR (ChIP-qPCR) 相结合
基因相互作用研究的研究.

主要成果:

SWI2/SNF2-RELATED 1 (SWR1) 综合体和SET DOMAIN GROUP 2 (SDG2) 与ERECTA (ER) 信号通路发生基因相互作用.
这个SWR1-SDG2-ER模块将巨胞母细胞命运限制在卵子原始体内的单个细胞上.
信号通路促进BZR1转录因子在miRNA处理基因 (HYL1,DCL1,SE) 上的积累,激活它们的表达.

结论:

一个涉及表观遗传因素和受体激酶信号传递的新型基因调节网络控制了Arabidopsis雌性生殖线的发展.
这些发现揭示了表观遗传修饰和信号通路如何合作,以确保适当的介质启动和生殖线发育.
这项研究为植物性繁殖的分子基础提供了基本的见解.

关键词:

阿拉比多普西斯 (Arabidopsis) 是一种植物.在BZR1中.埃雷克塔 (Erecta) 是一个国家.可持续发展目标2 SDG2 这就是SWR1的原因.巨胞母细胞是巨胞母细胞中的一个.

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