过度的孕期体重增加会改变DNA甲基化,并影响胎儿和新生儿的身体组成
Perla Pizzi Argentato1, João Victor da Silva Guerra2, Liania Alves Luzia1
1Nutrition Department, School of Public Health, University of São Paulo, Avenida Dr. Arnaldo 715, São Paulo 01246-904, SP, Brazil.
Epigenomes
|August 22, 2023
概括
过度的孕期体重增加与改变的DNA甲基化有关,影响胎儿和新生儿的身体组成. 这种表观遗传变化可能会增加后代的慢性疾病风险.
科学领域:
- 表观遗传学和发育生物学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 人体生理学 人体生理学
背景情况:
- 孕期体重增加 (GWG) 影响母亲和后代的健康结果.
- 基因甲基化 (DNAm) 是一种关键的表观遗传机制,对体重变化等环境因素敏感.
- 通过DNAm了解母体GWG和后代身体组成之间的相互作用对于早期健康评估至关重要.
研究的目的:
- 研究母体DNA甲基化模式与胎儿和新生儿身体组成之间的关联.
- 为了比较具有充足GWG与过度GWG (EGWG) 的母亲的DNAm.
- 为了确定特定的基因和受母体GWG相关DNAm影响的生物学途径.
主要方法:
- 这项研究包括来自阿拉库拉拉队列研究的巴西孕妇.
- 根据怀孕前的BMI,参与者被分为适当的GWG (AGWG) 和EGWG组.
- 使用Illumina甲基化EPIC阵列分析母亲的DNAm;通过超声波和plethysmography评估胎儿和新生儿的身体组成.
主要成果:
- EGWG组表现出更高的母体体重,GWG,新生儿体重和脂肪质量.
- 在不同组之间确定了46个差异甲基化位置和11个差异甲基化区域 (DMR).
- 母亲DNAm与胎儿组织和脂肪以及新生儿脂肪质量百分比相关;DMRs为胰岛素抵抗和高血糖等术语进行了丰富.
结论:
- 在EGWG中的母体DNAm模式与胎儿和新生儿身体组成的改变有关.
- 这些表观遗传变化表明后代患慢性疾病的风险增加.
- 强调母亲表观遗传学在胎儿发育和长期健康规划中的作用.
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