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培养抗微生物耐药性:密集农业如何为抗生素耐药性铺平道路
Matthew Kelbrick1, Elze Hesse2, Siobhán O' Brien3
1Department of Evolution, Ecology and Behaviour, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK.
Microbiology (Reading, England)
|August 22, 2023
概括
由于密集农业,全球抗菌素耐药性 (AMR) 正在上升. 环境压力因素,不仅仅是抗生素,驱动微生物群体中的AMR进化,需要采取更广泛的方法.
科学领域:
- 环境科学 环境科学
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 抗菌素耐药性 (AMR) 构成了对公共卫生,粮食安全和动物福利的重大全球威胁.
- 尽管有抗生素管理倡议,但AMR在全球范围内继续增加.
- 当前的战略往往忽视了密集农业在自然微生物群落内的抗药性传播中的作用.
研究的目的:
- 审查人为环境压力因素对AMR的演变和传播的影响.
- 探索非抗生素因素在微生物生态系统中驱动AMR的机制.
- 突出需要一种跨学科的方法来打击AMR超出临床环境.
主要方法:
- 对影响AMR的环境因素现有文献的审查.
- 分析诸如交叉电阻,共电阻和共调节等机制.
- 检查温度波动,土壤盐度,肥沃性损失,金属和农药的影响.
主要成果:
- 人类造成的压力因素,如温度变化,盐度和污染物,可以独立于抗生素的使用来选择AMR.
- 这些压力因素可以促进细菌生理学,可能促进*de novo*AMR进化.
- 现有的研究主要集中在单一物种上,缺乏对社区级AMR农业动态的洞察力.
结论:
- 环境因素对抗药物耐药性的演变和传播有着显著的贡献,远远超出了临床领域.
- 强化农业实践创造了促进复杂微生物群落中AMR的条件.
- 一个全面的,多学科的战略对于解决抗菌素耐药性的多方面的驱动因素至关重要.
关键词:
抗菌药物反症 (AMR) 是一种人类世 (Anthropocene) 是一个人类世.农业 农业 农业 农业抗生素 抗生素是一种抗生素.的交叉电阻.进化 演化 演化 演化 演化 演化 演化 演化土壤土壤土壤土壤土壤更多相关视频
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