在莫斯微图外科手术中抗焦虑药物的有效性和安全性:一个随机,双盲,安慰剂控制的试验
Danny Guo1, David M Zloty2, Irèn Kossintseva2
1Division of Dermatology, University of Calgary, Calgary, Alberta, Canada.
概括
迪亚泽帕有效地减少了莫斯手术期间的焦虑,与其他测试的药物不同. 这项研究突出显示,在这种门诊手术中,迪亚泽巴姆是治疗患者焦虑的安全有效选择.
科学领域:
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
- 手术麻醉手术麻醉
背景情况:
- 患者的焦虑会对手术结果产生负面影响,包括血压,疼痛管理和满意度.
- 有限的比较数据存在于莫斯微图外科手术中的抗焦虑疗效和安全性.
- 使用程序前抗焦虑药物,但它们的比较有效性尚未得到充分证实.
研究的目的:
- 在莫斯手术中比较各种手术前抗焦虑剂的有效性和安全性.
- 评估这些药物对患者外科手术期间焦虑的影响.
- 评估对患者满意度的影响.
主要方法:
- 一个双盲,随机,安慰剂对照试验,涉及350名接受莫斯手术的患者.
- 六种抗焦虑药物被测试:洛拉泽帕姆,迪亚泽帕姆,阿尔普拉佐拉姆,加巴丁,普雷加巴林和黑激素.
- 焦虑程度和生命体征被系统地记录下来.
主要成果:
- 与安慰剂 (p = .03) 相比,糖尿病显示出统计学上显著的,持续的焦虑减轻.
- gabapentin显著减少了早期焦虑 (p = .02),而alprazolam显示了一个趋势 (p = .08).
- 洛拉泽巴姆,普雷加巴林和黑激素并没有显著减少焦虑;没有任何药物影响了生命体征或认知.
结论:
- 单次口服剂量为5毫克的泽在莫斯手术中提供持续的焦虑缓解作用,并具有出色的安全性.
- 短效的二类药物和GABA药物可能会提供暂时的缓解.
- 迪亚泽帕姆成为莫斯手术患者管理焦虑的首选药物.
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