预防性预防预防艾滋病毒:美国预防服务工作组建议声明
, Michael J Barry1, Wanda K Nicholson2
1Harvard Medical School, Boston, Massachusetts.
JAMA
|August 22, 2023
概括
与抗逆转录病毒治疗的暴露前预防对艾滋病毒感染风险较高的个体有显著的益处. 这种艾滋病毒预防策略为公众健康带来了巨大的净益.
科学领域:
- 公共卫生
- 预防传染病
- 临床医学
背景情况:
- 美国有超过120万人感染艾滋病毒, 自1981年以来已有超过76万人死亡.
- 尽管艾滋病毒是可以治疗的,
- 有效的艾滋病毒预防策略对于公共卫生和临床实践至关重要.
研究的目的:
- 评估暴露前预防 (PrEP) 预防艾滋病毒的益处和危害.
- 评估风险评估工具的准确性,以识别高风险感染艾滋病毒的人.
主要方法:
- 美国预防服务工作组 (USPSTF) 委托进行系统审查.
- 对抗逆转录病毒疗法的评估
- 对艾滋病毒风险评估工具的诊断准确性的分析.
主要成果:
- 有效的抗逆转录病毒治疗对减少艾滋病毒风险的显著净益处的高度确定性.
- 作为暴露前预防的抗逆转录病毒治疗对预防艾滋病毒的感染是有效的.
- 风险评估工具有助于识别需要HIV预防干预的个人.
结论:
- 对于艾滋病毒风险较高的人来说,USPSTF建议使用有效的抗逆转录病毒疗法进行暴露前预防.
- 这项建议旨在减少艾滋病毒感染的发生率.
- 临床医生应考虑对有风险的人群开处方PrEP.
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