剂对特定的口腔病原体的抗微生物疗效
Ulrica Scherdin Almhöjd1, Anna Lehrkinder2, Ann-Marie Roos-Jansåker3
1Department of Cariology, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, Box 450, SE-405 30, Gothenburg, Sweden. ulrica.almhojd@odontologi.gu.se.
Clinical oral investigations
|August 22, 2023
概括
低酸盐剂显示出作为控制口腔病原体的赫西丁 (CHX) 替代品的希望. 这些药物具有快速的抗菌作用,有可能减少与CHX相关的不良影响,用于治疗口腔感染.
科学领域:
- 口腔微生物学 口腔微生物学
- 抗微生物药物的有效性测试.
- 牙科材料科学 牙科材料科学
背景情况:
- 口腔感染,包括牙和牙周炎,通常是由多微生物生物膜引起的.
- 赫西丁 (CHX) 是一种广泛使用的抗微生物药物,但其使用可能会产生不良影响.
- 需要替代抗菌剂来有效管理口腔病原体和生物膜.
研究的目的:
- 为了比较化 (NaOCl) 溶液 (Perisolv®,Carisolv®,达金溶液) 与常见的口腔病原体的抗微生物疗效.
- 通过使用标准抗微生物分析,对这些NaOCl剂进行氧化 (CHX) 和过氧化 (H2O2) 的评估.
- 为了确定测试剂的最小抑制度 (MIC) 和最小杀菌度 (MBC).
主要方法:
- 十个与牙和牙周炎相关的口腔微生物被挑战了Perisolv®,Carisolv®,达金溶液,CHX和H2O2.
- 剂量标准化为70 mmol/L的活性的度.
- 评估了抗微生物活性,使用阿加扩散,微稀释和活/死活力测试.
主要成果:
- 除H2O2和Perisolv®氨基酸外,所有药物都表现出抗菌作用.
- 对于抑制微生物生长,CHX在阿加扩散和汁微稀释中最有效.
- 达金溶液在汁稀释试验中表现出最强的杀菌度.
- 活/死分析显示,Aggregatibacter actinomycetemcomitans和Streptococcus mutans对不同毒剂的敏感性各不相同.
结论:
- 经过测试的低化物剂在控制口腔病原体方面显示出作为CHX的替代品的巨大潜力.
- 这些药物表现出快速的抗菌作用,提供临床优势.
- 用低化物剂代替CHX可能会减轻与CHX使用相关的不良影响.
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