热素110对机会性病原体Cutibacterium acnes的抗菌活性
John A Renye1, Mayra A Mendez-Encinas2, Andre K White3
1Dairy and Functional Foods Research Unit, Agricultural Research Service, USDA, 600 E. Mermaid Lane, Wyndmoor, PA, 19038, USA. john.renye@usda.gov.
Biotechnology letters
|August 22, 2023
概括
热素110是一种细菌素,有效地抑制了Cutibacterium acnes的生长和生物膜的形成. 水凝配方显示出提供这种抗微生物或益生菌细菌用于治疗的前景.
科学领域:
- 微生物学 微生物学
- 生物技术是生物技术.
- 皮肤病学 皮肤病学
背景情况:
- Cutibacterium acnes是一种皮肤细菌,与和深层组织感染有关.
- 细菌素,如来自Streptococcus thermophilus的Thermophilin 110,显示出抗菌潜力.
研究的目的:
- 为了评估Thermophilin 110对Cutibacterium acnes的疗效.
- 评估水凝配方在传递Thermophilin 110或S. thermophilus方面的潜力.
主要方法:
- 评估Thermophilin 110对浮游生物C. acnes生长和生物膜形成的抑制.
- 将Thermophilin 110和S. thermophilus封装在阿拉比诺基兰 (AX) 和酸 (SA) 水凝中.
- 评估封装细菌素和细菌的抗菌活性.
主要成果:
- 热菲林110阻止了C. acnes浮游生物的生长 (≥160 AU mL-1),并抑制了生物膜的形成 (≥640 AU mL-1).
- 封装Thermophilin 110从当前的水凝配方中没有有效扩散.
- 完整的SA凝和从AX凝释放的S. thermophilus显示出对C. acnes.的抑制区域.
结论:
- 热素110显示出作为抗菌剂的潜力,用于C. acnes感染.
- 优化的SA和AX水凝可以作为细菌素或产生细菌素的益生菌的输送系统.
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