胃肠道参与后急性冠状病毒病 (COVID-19) 综合征的发生
Uday C Ghoshal1, Ujjala Ghoshal2
1Department of Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow.
冠状病毒疾病 (COVID-19) 可能导致长期的胃肠道 (GI) 问题,包括COVID-19后的肠-大脑相互作用 (DGBI) 障碍. 患有COVID-19的患者在感染后更有可能患上易怒肠综合征 (IBS).
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 神经胃肠病学 神经胃肠病学
背景情况:
- 严重急性呼吸系统综合征冠状病毒-2 (SARS-CoV2) 影响肺部和胃肠道.
- 已知胃肠道感染,包括病毒感染,会导致肠-大脑相互作用 (DGBI) 的感染后疾病.
研究的目的:
- 审查COVID-19后的长期胃肠道后果.
- 专注于COVID-19后DGBI的发展,特别是易怒肠综合征 (IBS).
主要方法:
- 审查至少12个队列研究.
- 包括四项研究与对照组.
主要成果:
- 在COVID-19后的DGBI,特别是IBS,已在从COVID-19中康复的患者中记录.
- 风险因素包括女性性别,症状性COVID-19 (特别是胃肠道症状),疾病严重程度,厌氧,老年病,抗生素使用,住院治疗,持续的胃肠道症状和心理健康因素.
- 假设的机制包括肠道运动的改变,内脏过敏,微生物群失调,炎症,免疫激活,增加肠道透性,以及肠内分泌系统和血清素代谢的变化.
结论:
- 长期的SARS-CoV2感染后果是常见的.
- 与健康人相比,患有COVID-19的患者患上COVID-19后IBS的可能性更高.
- 在COVID-19后,IBS可能会成为未来的医疗负担.
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