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Updated: Jul 18, 2025

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在状细胞肺癌中,体质重组导致FGFR1的瘤性域外缺失

Florian Malchers1, Lucia Nogova2, Martijn Ha van Attekum1

  • 1University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany Germany.

The Journal of clinical investigation
|August 22, 2023
PubMed
概括

在平细胞肺癌 (SQLC) 中频繁的8p11-p12放大与FGFR1依赖有关. 由特定的基因组重组驱动的新型ectodomain缺陷FGFR1变异解释了治疗耐药性,并可能预测治疗反应.

关键词:
药物治疗是药物治疗.遗传学 是一个遗传学.肺癌是一种肺癌.在瘤学瘤学.

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