在治疗轻度神经认知障碍的过程中,通过骨进行脉冲刺激
Tommy Kwan Hin Fong1, Teris Cheung2, Sze Ting Joanna Ngan1
1Department of Psychiatry, The University of Hong Kong, Hong Kong, China.
Annals of clinical and translational neurology
|August 22, 2023
概括
超皮脉冲刺激 (TPS) 在轻度神经认知障碍 (NCD) 的老年人中显著改善了认知能力. 这种非药理学方法在延缓老年人认知能力下降方面显示出有前途.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 神经学 神经学
背景情况:
- 对轻度神经认知障碍 (NCD) 的药理疗法具有有限的有效性和潜在的副作用.
- 超脉冲刺激 (TPS) 是一种使用聚焦超声波的非侵入性脑刺激技术.
- 之前的研究表明TPS在重大NCD中有效,但其对轻度NCD的影响尚不清楚.
研究的目的:
- 评估神经导航TPS在轻度NCD的老年人中的有效性和耐受性.
- 评估TPS干预后的认知和生化变化.
- 确定TPS作为轻度NCD治疗的潜力.
主要方法:
- 一项涉及老年人被诊断患有轻度非传染性疾病的开放性研究.
- 参与者接受了为期两周的神经导航TPS干预 (3次/周).
- 认知功能使用HK-MoCA,口语流利性测试,Stroop测试和中文IADL进行评估. 还分析了血清BDNF水平和APOE基因型.
主要成果:
- 19名参与者完成了这项研究,没有严重的不良影响.
- 在干预后的HK-MoCA,口头流利测试,Stroop干扰和中国IADL得分中观察到有统计学意义的改善.
- 在血清脑源性神经营养因子 (BDNF) 水平上没有发现显著变化.
结论:
- 神经导航的TPS显著提高了轻度NCD的老年人的认知功能.
- 在老年人中,TPS显示出延迟认知衰退的潜力.
- 建议进行进一步的大规模,随机化,假控制试验,以确认长期影响.
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