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Updated: Jul 18, 2025

Studying RNA Interactors of Protein Kinase RNA-Activated during the Mammalian Cell Cycle
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Studying RNA Interactors of Protein Kinase RNA-Activated during the Mammalian Cell Cycle

Published on: March 5, 2019

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SARS-CoV-2 核体蛋白通过 RNA 结合域 N2b 抑制 PKR 介导的综合应激反应

Chiara Aloise1, Jelle G Schipper1, Arno van Vliet1

  • 1Virology Section, Division of Infectious Diseases and Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.

PLoS pathogens
|August 22, 2023
PubMed
概括

SARS-CoV-2 核体蛋白 N 通过与 dsRNA 结合来抑制先天免疫,防止 PKR 激活和干扰素反应. 这种由N2b域介导的机制对于病毒复制至关重要,并且在其他冠状病毒中得到保护.

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