在细胞培养和小鼠中,SARS-CoV-2 Mac1是IFN对抗性和有效病毒复制所需的

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Updated: Jul 18, 2025

Single-cell Quantitation of mRNA and Surface Protein Expression in Simian Immunodeficiency Virus-infected CD4+ T Cells Isolated from Rhesus macaques
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Single-cell Quantitation of mRNA and Surface Protein Expression in Simian Immunodeficiency Virus-infected CD4+ T Cells Isolated from Rhesus macaques

Published on: September 25, 2018

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Yousef M Alhammad1, Srivatsan Parthasarathy1, Roshan Ghimire2

  • 1Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66047.

Proceedings of the National Academy of Sciences of the United States of America
|August 22, 2023
PubMed
概括

冠状病毒的Mac1蛋白对于MERS-CoV和MHV的毒性至关重要,但对于SARS-CoV-2的复制并非如此. 在SARS-CoV-2中删除Mac1降低了其致病性并增强了免疫反应,将Mac1确定为潜在的抗病毒标.

关键词:
在ADP-ribosylation过程中.这就是SARS-CoV-2病毒.冠状病毒冠状病毒的新冠病毒.干扰子干扰子干扰子宏观领域是一个宏观领域.

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