基于天然抗氧化剂的纳米药物用于动脉样硬化治疗
Xiaoluan Lu1, Zhongshan He2, Xiao Xiao1
1College of Biomedical Engineering and National Engineering Research Center for Biomaterials, Sichuan University, 29 Wangjiang Road, Chengdu, 610064, China.
Small (Weinheim an der Bergstrasse, Germany)
|August 22, 2023
概括
一种新型纳米药物,维生素C (VC) 装入脂肪酸 (LA) 囊泡 (VC@cLAVs),通过增强抗氧化能力和延长血液半衰期,有效治疗动脉样硬化.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 心血管研究研究心血管研究
背景情况:
- 由于安全性,天然抗氧化剂对动脉样硬化症 (AS) 治疗有希望.
- 有限的活性氧物种 (ROS) 消除和快速的新陈代谢阻碍了AS治疗中的天然抗氧化剂疗效.
研究的目的:
- 开发一种新型纳米药物 (VC@cLAVs),用于加强动脉样硬化治疗.
- 克服天然抗氧化剂的局限性,包括短半衰期和低效率.
主要方法:
- 将维生素C (VC) 装入由脂酸 (LA) 构成的交联囊泡 (VC@cLAVs).
- 通过氧化还原对循环 (LA/DHLA和VC/DHA) 评估纳米药物的抗氧化能力.
- 在无脂蛋白E缺乏的小鼠模型中评估体内疗效.
主要成果:
- VC@cLAVs显著增加了天然抗氧化剂的血液半衰期.
- 通过相互回收氧化还原对来实现了增强的抗氧化能力.
- VC@cLAVs在小鼠中的斑块面积从52%降低到13%,超过了自由的VC和LA.
结论:
- 开发的基于天然抗氧化剂的纳米药物 (VC@cLAVs) 在治疗动脉样硬化方面表现出卓越的疗效.
- 在AS治疗中,VC@cLAVs具有显著的临床应用潜力.
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