炎症性肠病是肥胖个体代谢功能障碍相关的肥胖性肝病的独立危险因素
Samuel J Martínez-Domínguez1,2,3, Sandra García-Mateo1,2,3, Carla J Gargallo-Puyuelo1,2,3
1Department of Gastroenterology, Lozano Blesa University Hospital, Zaragoza, Spain.
Inflammatory bowel diseases
|August 22, 2023
概括
炎症性肠病 (IBD) 与更高的代谢功能障碍相关的脂肪性肝病 (MASLD) 在瘦个体中的患病率有关. 即使考虑到传统的代谢风险因素,这种关联仍然存在.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 内部医学 内部医学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 通常与肥胖有关.
- 新出现的证据突出显示,MASLD在瘦身个体中的发展.
- 炎症性肠病 (IBD) 可能会影响MASLD的风险,特别是在非肥胖人口中.
研究的目的:
- 确定患有IBD的瘦个体中MASLD和显著肝纤维化的患病率.
- 在瘦肉IBD患者中识别与MASLD和纤维化相关的风险因素.
- 为了比较瘦体IBD患者和瘦体对照之间的MASLD患病率.
主要方法:
- 进行了一项横截面的病例控制研究.
- 招募了300名患有IBD (病例) 的瘦人群和80名没有IBD的瘦人群对照.
- 所有参与者都进行了肝脏超声波,过渡性弹性成像和实验室测试.
主要成果:
- 与瘦肉对照 (10%) 相比,IBD的瘦肉个体表现出MASLD (21.3%) 的流行率显著更高.
- 两组之间没有观察到晚期肝纤维化患病率的显著差异.
- 在瘦个体中,IBD被确定为MASLD的独立风险因素,即使经过对代谢因素和类固醇使用进行调整.
结论:
- MASLD在IBD瘦人群中比IBD瘦人群中更为普遍.
- 这种增加的患病率是独立于常见的代谢风险因素.
- 在瘦肉的人群中,IBD是MASLD的重要风险因素.
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