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对SARS-CoV-2主要蛋白酶抑制剂Nirmatrelvir的多组分合成

H Daniel Preschel1, Ruben T Otte1, Ying Zhuo2

  • 1Department of Chemistry & Pharmaceutical Sciences, Amsterdam Institute of Molecular & Life Sciences (AIMMS), Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.

The Journal of organic chemistry
|August 22, 2023
PubMed
概括

开发了一种新的,高效的合成nirmatrelvir,一个口服抗病毒治疗COVID-19的药物. 这个过程利用生物催化和多元组件反应,避免过渡金属,以更绿色,更经济地生产这种重要药物.

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Subviral Agents01:29

Subviral Agents

Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
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