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百合素通过调节花生敏感BALB/c小鼠PI3K/AKT通路来减轻食物过敏

Hongjuan He¹, Xiaoyan Ji¹, Lihua Cao¹

¹Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Henan, Zhengzhou 450046, China.

|August 22, 2023

概括

百合素有效地减少了小鼠的花生过敏症状,通过降低关键的炎症标志物和缓解肠道炎症. 这项研究突出了利科的重要性.

科学领域:

免疫学免疫学免疫学
营养科学营养科学
胃肠病学胃肠病学

背景情况:

食物过敏,如花生过敏,由于严重的急性症状,造成严重的公共健康风险.
迫切需要有效的预防和治疗食物过敏的策略.
建立了原始花生蛋白提取物 (PPE) 诱导过敏的小鼠模型,以研究潜在的治疗剂.

研究的目的:

为了研究柳科对花生过敏的治疗作用.
评估烯对关键过敏反应指标和炎症通路的影响.

主要方法:

使用原始花生蛋白提取物 (PPE) 诱导花生过敏的小鼠模型.
小鼠接受了不同剂量的柳科 (5毫克/公斤,20毫克/公斤) 或没有接受治疗.
使用ELISA测量免疫球蛋白E (IgE) 和IL-13的血清水平.
通过病理学和免疫组织化学分析小肠组织,以评估炎症,组胺,小鼠大细胞蛋白酶-1 (MMCP-1) 和PI3K/AKT1表达.

主要成果:

莱科的使用显著降低了血清中的PPE特异性IgE和IL-13水平.
用莱科治疗减轻了小肠炎症.
百合素减弱了组胺和MMCP-1的产生.
小肠组织中PI3K和AKT1的表达被烯降低.

结论:

百合显示出作为治疗剂的潜力,可以改善花生过敏.
百合素通过调节PI3K/AKT通路来发挥其抗过敏作用.
这些发现表明,可可以减轻由PPE特异性IgE介导的过敏反应.

关键词:

食物过敏食物过敏在 IgE 中,IgE 是这种药物是百合素 (Lycopene).通过PI3K/AKT路径.这是一个花生花生,花生花生.

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