结肠镜的时间和宫癌的风险
Stephanie Alimena1, Jacquelyn M Lykken, Jasmin A Tiro
1Division of Gynecologic Oncology, Brigham and Women's Hospital, and the Division of General Internal Medicine, Massachusetts General Hospital, Harvard Medical School, Boston; Massachusetts; Department of Population & Data Sciences and the Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, and the Parkland Health and Hospital System, Dallas, Texas; the Department of Public Health Sciences, University of Chicago Biological Sciences Division, Chicago, Illinois; the Kaiser Permanente Washington Health Research Institute, Seattle, Washington; and the Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland.
在异常宫癌查后及时进行结肠镜检查至关重要. 延迟或跳过这种后续检查会显著增加患子宫癌的风险.
科学领域:
- 妇科 妇科 妇科 妇科
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 宫癌查可以早期检测出异常.
- 及时对前镜进行后续检查对于管理癌前变化至关重要.
研究的目的:
- 为了确定镜检查时间与随后的宫癌诊断风险之间的关联.
- 为了评估延迟或缺失镜对子宫癌风险的影响.
主要方法:
- 对超过17000名21-79岁的患有异常宫癌检测结果的21000多名患者进行了纵向分析.
- 对宫癌诊断率的比较,基于镜时间:在3个月内,3-12个月内,没有镜在12个月内.
- 用多变量考克斯比例危险回归来控制混因素.
主要成果:
- 在12个月内没有接受结肠镜检查的患者,与在3个月内接受结肠镜检查的患者相比,患子宫癌的风险增加了2.34倍.
- 对于高等级细胞学结果,没有及时进行结肠镜检查的患者,子宫癌的风险是3.12倍.
- 在3个月内进行全息镜检查和在3-12个月内进行全息镜检查之间没有发现显著的风险差异.
结论:
- 与及时手术相比,延迟镜检查超过3个月并没有增加子宫癌的风险.
- 如果在12个月内没有接受镜检查,那么患子宫癌的风险会显著增加.
- 在异常查测试后迅速进行镜检查对于预防晚期子宫癌至关重要.
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