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基于物理的模拟3D生物打印球体的弹性-塑料融合

Hassan Bahrami¹, Federico Sichetti², Enrico Puppo²

¹Faculty of Engineering and Information Technology, University of Technology Sydney, 15 Broadway, Ultimo NSW 2007, Australia.

|August 22, 2023

概括

本研究介绍了一种基于物理的模拟框架,用于控制3D生物打印组织的形状和大小. 该模拟准确地模拟了球状聚变,使得可以精确控制再生医学应用的组织发育.

科学领域:

生物技术和生物医学工程生物技术和生物医学工程
组织工程是组织工程.
计算生物学计算生物学

背景情况:

球体是微组织,用于作为3D生物打印人体组织的构建块.
控制球状融合对于确定生物打印组织的最终形状和尺寸至关重要.
现有的方法缺乏精确控制球形聚变过程.

研究的目的:

开发第一个基于物理的框架来模拟3D生物打印中的球体融合.
研究各种参数对球体融合动态和由此产生的组织形态的影响.
为控制和监测球形自组合的几何结果提供一个工具.

主要方法:

利用了弹性-塑料固体和流体连续力学模型.
采用光滑粒子水力学 (SPH) 方法进行模拟.
进行了灵敏度和形态分析,以验证与体外球体相对应的模拟.

主要成果:

拟议的框架准确地模拟了融合球体的弹性-塑性行为.
通过调整模拟参数来证明对组织形状和大小的控制.
经验证的in-silico结果与体外实验数据.

结论:

开发的基于物理的模拟提供了一个强大的框架来控制球形聚变.
这项技术对推进3D生物打印和组织工程具有重大意义.
能够精确地设计具有所需形状和尺寸的组织结构.

关键词:

在3D生物打印中使用3D生物打印弹性-塑料的弹性-塑料基于物理的模拟.球形形状的球形状

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Plastic Behavior

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