含有10-hydroxycamptothecin的基于粉的微囊,具有针对目标控制释放的逐步响应释放策略
Qingye Meng1, Shuangling Zhong2, Jia Wang1
1College of Chemistry, Jilin University, Changchun 130012, PR China.
International journal of biological macromolecules
|August 22, 2023
概括
研究人员开发了对谷氨 (GSH) 敏感的微囊 (FA-RSMCs) 用于向癌症治疗. 这些微囊提供一种对活性氧物种 (ROS) 敏感的药物,增强抗瘤功效并保护正常细胞.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 控制药物释放对于有效的癌症治疗至关重要,旨在最大限度地降低对健康组织的毒性.
- 开发有针对性的输送策略可以提高药物可用性和治疗效果.
- 谷氨 (GSH) 和活性氧物种 (ROS) 是瘤微环境中的关键生物标志物.
研究的目的:
- 设计新型的对谷氨 (GSH) 敏感的微囊 (FA-RSMCs) 用于针对性地输送10-氧营托丁 (HCPT).
- 在微囊中创建一个逐步释放药物系统,利用ROS响应的多种药物.
- 评估联反应释放,抗瘤疗效和开发的输送系统的安全性在体外.
主要方法:
- 硫化改性粉基微囊 (FA-RSMCs) 的声化学制剂.
- 一种反应性氧物种 (ROS) 响应的多种药物 (polyHCPT) 的设计,装入微囊.
- 在实验室评估GSH和ROS触发的级联药物释放在模拟瘤微环境中.
- 在体外细胞毒性和抗瘤活性的评估.
主要成果:
- FA-RSMCs证明了成功的GSH响应裂变,释放了多HCPT.
- 随后PolyHCPT经历了ROS响应的裂变,释放完整的HCPT药物分子.
- 该系统在体外表现出有利的级联反应释放特性.
- 在细胞毒性测试中,FA-RSMCs显示出显著的抗瘤能力和保护正常细胞.
结论:
- 开发的FA-RSMCs提供了一种基于瘤微环境触发器的逐步药物释放的有希望的策略.
- 这种有针对性的输送系统提高了癌症治疗中HCPT输送的准确性和安全性.
- 在未来,FA-RSMCs有可能在瘤学中进行临床应用.
相关概念视频
01:15Drugs that Stabilize Microtubules
2.1K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.1K
01:10Drugs that Destabilize Microtubules
2.0K
Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
2.0K