对焦虑和抑郁症的积极性治疗的扩大:一个随机的实验治疗试验,针对社会奖励敏感性,以增强社会联系
Charles T Taylor1, Murray B Stein2, Alan N Simmons2
1Department of Psychiatry, University of California San Diego, San Diego, California.
Biological psychiatry
|August 22, 2023
概括
针对积极价值过程的认知和行为策略改善了焦虑和抑郁症的成年人的社会奖励反应和联系. 阳性放大 (AMP) 治疗增强了条形状活动和社会联系,五次剂量显示出更大的效果.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 心理学 心理学 心理学
背景情况:
- 在焦虑和抑郁障碍中,社会断绝是普遍存在的,往往治疗不当.
- 对于社会联系至关重要的正价值系统在这些条件下经常过度响应.
- 现有的焦虑和抑郁症治疗方法在解决社会障碍方面表现出有限的有效性.
研究的目的:
- 测试通过认知和行为策略准积极的价值过程是否能提高社会奖励响应度.
- 研究积极性放大 (AMP) 对社会联系的影响.
- 检查不同的AMP治疗剂量对神经和行为结果的影响.
主要方法:
- 一项随机对照试验涉及68名成年人,他们有高度的焦虑/抑郁和社会障碍.
- 参与者被分配到AMP治疗的5或10次会议或等候名单控制.
- 主要结局:在社会奖励预测 (fMRI) 期间,条形状活动的变化;次要:社会归属任务和自我报告的社会联系.
主要成果:
- 与等待列表相比,AMP治疗在社会奖励预期期间显著增加了条形状激活.
- AMP改善了积极影响,在关联任务中的接近行为,以及社会联系.
- 一个5次会议的AMP剂量显示,与10次会议剂量相比,条形状活动和社会联系的增加更大.
结论:
- 增强积极性的认知和行为策略可以增强焦虑和抑郁症患者对社会奖励的神经反应.
- 这种方法促进了社会联系,表明社会奖励敏感性是一个可行的跨诊断治疗目标.
- 积极性的放大 (AMP) 为情绪和焦虑障碍中的社会缺陷提供了一个有希望的治疗途径.
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