体重和身高的发展 经过全腔肺连接后的年龄z-Score
Carlo Bilic1, Helena Staehler1, Carolin Niedermaier1
1Department of Congenital and Pediatric Heart surgery, German Heart Center Munich, Technische Universität München, Munich Germany, Division of Congenital and Pediatric Heart Surgery, University Hospital of Munich, Ludwig-Maximilians-Universität, Munich, Germany.
The Thoracic and cardiovascular surgeon
|August 22, 2023
概括
接受全腔肺连接 (TCPC) 的患者体重有所改善,但身高的增长没有达到. 之前的双向腔肺突变 (BCPS) 具有保护性,而诺伍德手术的左心肺低塑性综合征 (HLHS) 则存在风险.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 生产性心脏病 手术 手术 生产性心脏病
- 增长和发展 增长和发展
背景情况:
- 全腔肺连接 (TCPC) 是复杂的先天性心脏缺陷的缓解性手术程序.
- 在TCPC之后的体质生长是长期结果的关键指标.
- 影响术后生长的因素需要进一步调查.
研究的目的:
- 分析TCPC后儿科患者的体质生长 (体重和身高).
- 确定与追赶增长相关的术前和术后因素.
- 评估特定诊断和之前的手术程序对生长的影响.
主要方法:
- 对309名在4岁或更年轻时接受TCPC治疗的患者的回顾性分析.
- 在TCPC (1-3岁) 之前和之后计算体重与年龄的z-score (WAZ) 和身高与年龄的z-score (HAZ).
- 统计分析以确定影响WAZ和HAZ变化的因素.
主要成果:
- 在TCPC后观察到WAZ显著增加 (p < 0.001),但HAZ没有显著变化 (p = 0.38).
- 在TCPC中较大的年龄和低可塑性左心综合征 (HLHS) 是较低WAZ和HAZ的风险因素.
- 以前的双向腔肺突变 (BCPS) 是WAZ和HAZ的保护因素.
结论:
- 接受TCPC的儿科患者经历了显著的体重追赶增长,但不是身高追赶增长.
- 之前的BCPS与TCPC更好的体质发育有关.
- 接受诺伍德手术的HLHS患者面临TCPC后体质发育的风险增加.
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