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Yiming Shi1, Huilin Li2, Chan Wang2

  • 1Division of Biostatistics, Washington University in St. Louis, St. Louis, Missouri, USA.

Statistics in medicine
|August 22, 2023
PubMed
概括

我们介绍了一种灵活的准概率模型来分析微生物群计数数据,在没有严格的分布假设的情况下提供有效的统计推断. 这种在模拟和真实腺瘤研究中验证的方法可通过R包"fql"获得.

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Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
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Distributions to Estimate Population Parameter01:26

Distributions to Estimate Population Parameter

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A goodness-of-fit test is conducted to determine whether the observed frequency values are statistically similar to the frequencies expected for the dataset. Suppose the expected frequencies for a dataset are equal such as when predicting the frequency of any number appearing when casting a die. In that case, the expected frequency is the ratio of the total number of observations (n)  to the number of categories (k).
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Compartmental analysis is a widely adopted approach to characterizing drug pharmacokinetics. It uses compartment models that conceptualize the body as a collection of reversibly communicating compartments, each representing a group of tissues exhibiting similar drug distribution characteristics. The movement rate of the drug between these compartments is typically described by first-order kinetics.
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