超皮持续释放特性和抗光衰老功效的脂质体热敏凝系统的热敏凝系统
Sijie Wu1, Gaodan Liu1, Ping Shao1,2
1Department of Food Science and Technology, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014, China.
Advanced healthcare materials
|August 22, 2023
概括
这项研究开发了一种碳氧甲基修饰的奇托桑/氨酸水凝,用于持续的透皮药物输送. 脂质体-水凝系统有效地提供活性成分,增强抗光衰老效果和皮肤保留.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 皮肤病学 皮肤病学
背景情况:
- 药物输送系统在生物医学中至关重要.
- 纳入水凝的脂质体提供了强大的多功能系统,用于持续的局部输送.
- 开发先进的载体是有效的透皮疗法的关键.
研究的目的:
- 开发一种碳氧甲基修饰的奇托/氨酸 (CMC/HA) 热敏水凝,用于持续通过皮肤输送脂质体.
- 描述水凝的特性及其控制脂质体释放的能力.
- 评估脂质体-水凝系统在促进抗光衰老效果方面的有效性.
主要方法:
- 合成和表征CMC/HA热敏水凝 (CMH2) 具有特定的替代度 (DS = 18.20 ± 0.67%).
- 评估水凝特性:凝温度 (37.8°C),凝时间 (315秒),可扩散性,粘度和多孔结构.
- 评估脂质体释放动力学和体内抗光衰老功效通过水凝系统输送的阿斯科比尔葡萄糖化物 (AA2G).
主要成果:
- CMH2水凝在体温下表现出快速凝,并且具有适合皮肤应用的物理特性.
- 水凝有效地减缓了脂质体释放,在24小时内释放了33.92-49.35%的AA2G.
- 脂质体-水凝系统显著改善了皮肤保留,减少了表皮厚度,黑色素沉积和脂质氧化损伤,同时增加了原蛋白密度.
结论:
- 开发的CMC/HA热敏水凝是持续透皮药物递送的有希望的载体.
- 脂质体-水凝系统增强药物保留和疗效,为局部治疗提供了多功能方法.
- 该系统通过改善AA2G等活性化合物的输送和性能,显示出抗光衰老应用的巨大潜力.
相关概念视频
01:27Bioavailability Enhancement: Drug Permeability Enhancement
After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
01:30Modified-Release Drug Delivery Systems: Stimuli-Activated
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
01:24Modified-Release Drug Delivery Systems: Site-Targeted
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
01:18Transdermal Drug Delivery Systems
Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...