通过基因介导的THG-1/TSC22D4酸化促进状细胞癌瘤发生
Nohara Goto1,2, Hiroyuki Suzuki1,3, Ling Zheng1
1Department of Experimental Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Cancer science
|August 22, 2023
概括
转化生长因子β1刺激的克隆22 (TSC-22) 家庭蛋白THG-1 (TSC22D4) 驱动状细胞癌 (SCC) 的生长和入侵. 向THG-1酸化为SCC诊断和治疗提供了一个新的途径.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症研究 癌症研究
背景情况:
- 癌细胞表现出高增殖率和侵入性,对瘤进展至关重要.
- 遗传变化,包括驱动基因突变,是这些致瘤性质的基础.
- 关联瘤信号与这些攻击性特征的精确分子机制仍然不完全理解.
研究的目的:
- 阐明一种新的分子机制,将瘤信号连接到状细胞癌 (SCC) 的瘤性质.
- 研究THG-1 (TSC22D4) 蛋白在SCC发育和进展中的作用.
主要方法:
- 研究THG-1在正常和癌症组织中的局部化.
- 在SCC细胞中进行THG-1淘汰和过度表达实验.
- 分析了THG-1对扩散,侵入性和异种移植瘤形成的影响.
- 研究了通过RTK-RAS-ERK通路对THG-1的酸化.
- 评估THG-1参与CD44变体的替代拼接.
主要成果:
- THG-1在SCC中过度表达,并局限于正常皮表皮的基底层.
- 抑制THG-1抑制了SCC细胞的增殖,侵入性和瘤的生长.
- 过度表达THG-1增强了EGF诱导的增殖和分层表皮形成.
- 通过RTK-RAS-ERK通路的THG-1酸化促进了瘤基因介导的瘤发生.
- THG-1 影响 CD44 变体的拼接,影响侵袭性,干性和抗氧化应激性.
结论:
- THG-1在SCC瘤发生中起到新型的作用,将瘤信号与侵略性的细胞表型联系起来.
- THG-1酸化是RTK通路驱动的SCC的一个关键事件.
- 对THG-1酸化的特定抗体具有用于癌症诊断和治疗策略的潜力.
相关概念视频
Cancer-Critical Genes I: Proto-oncogenes
9.0K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.0K
Induced Pluripotent Stem Cells
4.2K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
Somatic...
4.2K
Abnormal Proliferation
4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
Cancer-Critical Genes II: Tumor Suppressor Genes
7.5K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.5K
The Retinoblastoma Gene
4.1K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.1K
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K


