了解在英格兰和威尔士的SELPHI随机对照试验中使用HIV自我测试的MSM (cis和trans) 中潜在危害的经验:一种混合方法研究
T Charles Witzel1,2, Emily Jay Nicholls2, Leanne McCabe3
1Department of Public Health, Environments and Society, London School of Hygiene & Tropical Medicine, London, UK c.witzel@ucl.ac.uk.
Sexually transmitted infections
|August 22, 2023
概括
艾滋病毒自我检测 (HIVST) 对与男性发生性关系的男性来说是安全的,很少报告危害. 解决技术伤害是HIVST更广泛实施和接受的关键.
科学领域:
- 公共卫生 公共卫生
- 性健康 性的健康
- 临床试验 临床试验
背景情况:
- 对艾滋病毒自我检测 (HIVST) 潜在危害的担忧阻碍了其广泛实施.
- 在SELPHI试验中,研究了在一个高收入国家的大规模公共卫生干预中,HIVST和伤害之间的关系.
研究的目的:
- 评估与男性发生性关系的 cis 和跨性别男性 (MSM) 艾滋病毒自我检测 (HIVST) 相关的危害的发生率和性质.
- 探索不同类型的伤害对HIVST的可接受性的影响.
主要方法:
- 一项大型随机试验 (SELPHI) 涉及英格兰和威尔士超过10,000名cis和transMSM.
- 参与者被随机分配到基线HIVST或没有基线测试,一个子组被随机分配到重复HIVST.
- 关于伤害 (关系,幸福感,错误结果,测试压力) 的数据是通过退出调查和深入访谈收集的.
主要成果:
- 危害是罕见的,只有4%的退出调查参与者报告.
- 1%报告对人际关系或福祉造成伤害;1%报告被迫进行测试;0.7%报告错误的阳性结果.
- 技术上的伤害降低了HIVST的接受度,而干预和社会上出现的伤害则没有.
结论:
- 艾滋病毒自我检测 (HIVST) 与MSM中罕见的危害有关.
- 建议在HIVST扩大规模方面采取战略,将遭受伤害的个人与心理社会支持联系起来.
- 用HIVST套件解决技术问题对于提高接受度至关重要.
相关概念视频
01:56Ethics in Research
23.1K
Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
23.1K
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
147
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
147
01:26Sexually Transmitted Infections
348
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
348