亚健康体检指标的关系链:使用PLS-SEM方法进行横截面研究
1School of Public Health, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Pudong, Shanghai, China.
Scientific reports
|August 22, 2023
概括
这项研究揭示了与次要健康相关的关键身体指标,确定了疲劳和四肢疼痛等常见症状. 它建立了一个关系链,从例行测试到舌下静脉特征,有助于早期的亚健康管理.
科学领域:
- 综合医学是一个整体的医学.
- 生物统计学 生物统计学
- 预防医学 预防医学
背景情况:
- 亚健康代表了最佳健康和诊断疾病之间的关键过渡阶段.
- 量化亚健康表现和解决身体检查数据的复杂性对有效干预提出了重大挑战.
- 常规体检为检测亚健康提供了一个窗口,需要对相关指标进行系统的调查.
研究的目的:
- 系统地调查不健康人口的体检指标.
- 探索体验亚健康的个体中各种健康指标之间的相互关系.
- 开发和验证一个结构模型,以了解子健康指标及其因果途径.
主要方法:
- 收集了878名受试者的数据,包括基本信息,西方医学指标,中国传统医学 (TCM) 询问和舌下静脉 (SV) 特性.
- 使用R软件进行统计分析,进行比较评估.
- 利用部分最小平方-结构方程建模 (PLS-SEM) 来分析症状分布,识别症状集群,并建立指标关系的结构模型.
主要成果:
- 常见的亚临床症状包括四肢疼痛 (37.6%),疲劳 (31.6%),肩和部疼痛 (30.5%),以及眼睛干燥 (29.2%).
- 与健康组相比,不健康组表现出较浅的舌下静脉 (SV) 红色 (p < 0.001).
- 验证的关系途径:常规血液检测脂质代谢 (p < 0.001),脂质代谢与肥胖 (p < 0.001),肥胖与SV特征 (p = 0.025),肝功能与SV特征 (p = 0.027).
结论:
- 该研究成功地在不健康人群中的体检指标之间建立了有针对性的非循环关系链.
- 应用PLS-SEM为探索亚健康机制和因果推理提供了一个新的框架.
- 识别典型的亚健康症状及其潜在的指标关系支持早期管理策略,可能防止疾病的进展.
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