骨髓炎作为Mycobacterium avium复杂肺部疾病的预后因素
Eunki Chung1, Youngmok Park1, Song Yee Kim1
1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Institute for Immunology and Immunological Disease, Yonsei University College of Medicine, Seoul, Republic of Korea.
Scientific reports
|August 22, 2023
概括
低勃起脊柱肌的霍恩斯菲尔德单位 (ESM HU),表明骨髓炎,与Mycobacterium avium复杂性肺病 (MAC-PD) 患者的死亡率增加有关. 在一些患者中,皮下脂肪区域提供了保护.
科学领域:
- 医疗成像医学成像
- 肺部病理学 肺部病理学
- 身体组成分析 身体成分分析
背景情况:
- 身体的定量组成会影响Mycobacterium avium复杂肺病 (MAC-PD) 的预后.
- 通过CT评估的定性身体组成在MAC-PD预后中的作用仍然不清楚.
研究的目的:
- 调查从CT扫描中获得的定性身体组成指标与MAC-PD患者的死亡率之间的联系.
- 为了确定肌骨瘤,通过起脊柱肌肉霍恩斯菲尔德单位 (ESM HU) 评估,预测MAC-PD的结果.
主要方法:
- 在诊断时接受非对比CT的377名MAC-PD患者的回顾性分析.
- 在L1脊椎水平测量勃起脊柱肌面积 (ESM面积),ESM霍恩斯菲尔德单位 (ESM HU) 和皮下脂肪面积 (SQF面积).
- 根据每个性别的ESM HU值中位数,定义骨髓炎.
主要成果:
- 在死亡的患者中观察到较低的ESM HU和SQF区域.
- 减少ESM HU与死亡率增加显著相关 (aHR 0.95,95% CI 0.93-0.97).
- 在BMI≥18.5kg/m2 (aHR0.98,95%CI0.95-1.00) 的患者中,SQF区域显示出保护作用.
结论:
- 减少ESM HU,表明骨髓炎,是MAC-PD死亡率的重要预测因素.
- 从CT获得的定性体质成分参数可以为MAC-PD患者提供预后信息.
- 皮下脂肪区域可能在某些患者群体的MAC-PD预后中起着保护作用.
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