同时使用MDMA和psilocybin/LSD可以缓冲具有挑战性的经历,并增强积极的经历
Richard J Zeifman1,2, Hannes Kettner3,4, Broc A Pagni5
1NYU Langone Center for Psychedelic Medicine, Department of Psychiatry, NYU Grossman School of Medicine, 1 Park Avenue, New York, NY, 10016, USA. richard.zeifman@nyulangone.org.
Scientific reports
|August 22, 2023
概括
将MDMA与psilocybin/LSD结合使用可能会减少诸如恐惧和悲伤等具有挑战性的经历. 这种组合似乎也增加了心理旅行期间的自我同情,爱和感激的感觉.
科学领域:
- 心理药理学 心理药理学
- 神经科学是一个神经科学.
- 心理健康研究 心理健康研究
背景情况:
- 使用psilocybin和LSD的迷幻体验可能具有挑战性,引起恐惧和偏执,这会阻止一些人接受迷幻辅助治疗.
- 事报告表明,与 псилоцибин/LSD同时服用3,4-甲基二氧化甲胺 (MDMA) 可能会减轻具有挑战性的经历,并增强积极的经历.
- 关于将MDMA与psilocybin/LSD结合的急性影响的经验研究有限.
研究的目的:
- 调查MDMA与psilocybin/LSD的联合使用是否与具有挑战性或积极主观体验的差异有关.
- 探索MDMA共用对特定挑战性 (恐惧,悲伤,偏执) 和积极 (自我同情,爱,感激) 经历在psilocybin/LSD使用期间的影响.
主要方法:
- 研究了698名计划使用 псилоцибин/LSD的人士的潜在便利样本.
- 27名参与者与psilocybin/LSD共同使用MDMA;他们的经验与单独使用psilocybin/LSD的人进行了比较.
- 使用了挑战性经验问卷和神秘经验问卷,以及自我同情,同情,爱和感恩的措施. 包括共变量在内.
主要成果:
- 同时使用psilocybin/LSD和低剂量的MDMA与明显较少的激烈挑战性经历有关,包括悲伤和恐惧.
- 与那些单独使用psilocybin/LSD的参与者相比,与使用psilocybin/LSD和MDMA的参与者报告了自我同情,爱和感激的增加.
- 两组之间在神秘类型的经历或同情心方面没有发现显著差异.
结论:
- 低剂量MDMA与psilocybin/LSD的同时使用可能会减轻某些具有挑战性的心理影响,并增强积极的情感体验.
- 研究结果表明,MDMA在迷幻疗法期间可能起到"缓冲"作用,尽管需要进一步研究.
- 在临床人群中,对MDMA和psilocybin/LSD联合使用的安全性和有效性的受控研究是个性化治疗开发的必要条件.
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