相关实验视频
Updated: Jul 18, 2025

07:15
Intranasal Administration of CNS Therapeutics to Awake Mice
Published on: April 8, 2013
59.3K
鼻内胰岛素用于COVID-19相关的气味损失
Dibildox Daniel1, Loyola-Nieto Paula2, Brenner-Muslera Eduardo2
1Hospital Medica Sur, Mexico City, Mexico. drdibildox@gmail.com.
概括
鼻内胰岛素的使用显著改善了COVID-19后慢性嗅觉丧失的患者的嗅觉功能. 这种治疗为由神经上皮损伤引起的嗅觉障碍提供了一个有希望的替代方案.
科学领域:
- 神经学 神经学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
背景情况:
- 嗅觉障碍 (低微,无微,幻微,微) 影响38%以上的COVID-19患者在急性感染后很长时间.
- SARS-CoV-2对ACE2的热带性表明嗅觉神经上皮和中枢神经系统参与的损伤.
- 嗅觉球的高胰岛素吸收率表明胰岛素对嗅觉功能障碍的潜在治疗益处.
研究的目的:
- 评估鼻内胰岛素在改善COVID-19后患者慢性嗅觉障碍方面的疗效.
- 在治疗4周后,使用Sniffin Sticks®门,歧视和识别 (TDI) 评分量化嗅觉改善.
主要方法:
- 一项前性研究涉及27名COVID-19后持续性嗅觉功能障碍患者 (感染后3-18个月).
- 通过Gelfoam®棉花进行 40 IU NPH 胰岛素的鼻内注射,持续 15 分钟,分为 4 个约会中的 3 次.
- 嗅觉功能在基线和4周后使用Sniffin Sticks® TDI得分进行评估.
主要成果:
- 93%的患者表现出嗅觉功能的改善.
- 平均TDI得分从基线67%显著增加到治疗后83% (p <0.01).
- 没有观察到干预前和后葡萄糖水平的显著变化.
结论:
- 鼻内胰岛素显示出有希望的结果,作为治疗慢性嗅觉障碍后的上呼吸道感染,如COVID-19的治疗.
- 这项研究是第一个使用三点TDI评分来评估COVID-19后患者的嗅觉,使用这种特定的鼻内胰岛素方案.
- 用Sniffin Sticks® TDI评分,适应拉丁语西班牙语,用于精确的嗅觉评估.
相关概念视频
Olfactory Receptors: Location and Structure
9.3K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
9.3K
Nose and Nasal Cavity
2.8K
The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...
2.8K
Physiology of Smell and Olfactory Pathway
8.7K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
The olfactory...
8.7K
Drugs Used in Upper Respiratory Disorders: Overview
290
Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
290
Inhaled Medications
308
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
308
Drug Delivery: Miscellaneous Routes
380
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
380

