不同卵细胞细胞质颗粒化模式对胚胎发育和euploidy的影响:一个兄弟卵细胞控制研究
Yali Wang1,2, Dongjia Chen1,2, Bing Cai1,2
1Reproductive Medicine Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, Guangdong, People's Republic of China.
Archives of gynecology and obstetrics
|August 23, 2023
概括
卵细胞细胞质粒度模式通常不会影响胚胎发育或受精. 然而,卵细胞中特定的中央粒度 (CG) 模式可能与较高的胚胎无体积率相关,需要进一步调查.
科学领域:
- 生殖生物学 生殖生物学
- 胚胎学 胚胎学
- 产卵细胞质量评估评估
背景情况:
- 细胞质颗粒是卵细胞的一个特征.
- 卵细胞细胞质颗粒和胚胎发育潜力之间的关系尚未完全理解.
研究的目的:
- 评估成熟卵细胞中细胞质颗粒化模式及其随后的发育潜力之间的关联.
- 为了调查特定的粒度模式是否影响胚胎发育的关键指标和染色体 ploidy.
主要方法:
- 分析了54个植入前遗传测试周期中的564个胚胎,使用时间延迟成像.
- 兄弟卵子细胞根据细胞质颗粒化模式分为四组:细 (FG),中心 (CG),分散 (DG) 和不均 (UG).
- 根据中央颗粒分布面积比率将CG集团分为I,II和III等级的分类.
主要成果:
- 在FG,CG,DG和UG群体之间没有发现受精率,形态动力学,胚胎细胞形成或动脉积分率的显著差异.
- 来自CG卵细胞的胚胎,特别是III级,与I级和II级相比,呈现出显著更高的无体积率.
- 临床结果,包括胚胎移植后的怀孕和活产率,在各组之间没有显著差异.
结论:
- 卵细胞细胞质颗粒化模式似乎并没有普遍影响胚胎受精,发育速度或无细胞化.
- 较高的中央颗粒度 (CG) 可能与增加的胚胎无倍化有关.
- 需要进行更大规模的研究来证实卵细胞细胞质颗粒对植入潜力的影响.
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