精神分裂症中杏仁体的异常:现实世界研究
Guangen Zheng1,2, Yang Zhou2, Jieming Zhou1
1Department of Psychiatry, The Third People's Hospital of Foshan, Guangdong, People's Republic of China.
BMC psychiatry
|August 23, 2023
概括
精神分裂症 (SC) 患者表现出杏仁体功能障碍和认知障碍. 虽然治疗改善了记忆功能,但杏仁体活动没有,这表明SC恢复中的解离.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 放射学 放射学是一门学科.
背景情况:
- 杏仁体在精神分裂症 (SC) 中起着至关重要的作用,但其精确的机制仍然不清楚.
- 研究SC中的杏仁体功能对于了解疾病和开发向疗法至关重要.
研究的目的:
- 探索桃体静态磁共振成像 (rsMRI) 信号与精神分裂症认知功能之间的关系.
- 为了解认知缺陷和SC治疗反应的神经基础提供见解.
主要方法:
- 收集了40名从未服用过药物的SC患者和33名健康对照 (HC) 的rsMRI数据.
- 利用rsMRI和自动细分来评估杏仁体体积和神经活动 (FALFF).
- 执行了与PANSS和RBANS分数的Pearson相关性分析,比较治疗前和治疗后的数据.
主要成果:
- 与HC患者相比,SC患者表现出广泛的认知障碍和显著的左桃体功能异常.
- 在SC患者中,即时记忆 (学习) 与FALFF有负相关性 (r = -0.343,在Bonferroni校正后p = 0.014).
- 虽然即时和延迟的记忆在治疗后得到改善,但杏仁体结构和功能没有显著的恢复.
结论:
- 在SC患者中存在显著的杏仁体功能障碍.
- 传统治疗改善了认知功能,特别是记忆,但没有恢复杏仁体功能,这表明恢复过程中的潜在解离.
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