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炎症性肠道疾病患者的疲劳 - - 受抑郁症的强烈影响,无法通过实验室检测识别:一个横截面调查研究
Victoria Uhlir1, Andreas Stallmach1, Philip Christian Grunert2
1Department of Internal Medicine IV, Jena University Hospital, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Germany.
BMC gastroenterology
|August 23, 2023
概括
疲劳显著影响炎症性肠病 (IBD) 患者,通常与抑郁症和生活质量下降有关,而不仅仅是疾病活动. 解决心理健康问题对于管理IBD相关的疲劳至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 临床医学 临床医学
- 精神病学是一个精神病学.
背景情况:
- 疲劳是患有炎症性肠病 (IBD) 患者的普遍和衰弱症状.
- 在IBD患者中,关于疲劳及其治疗选择的认识有限.
- 了解影响疲劳的因素是确定治疗点的关键.
研究的目的:
- 调查疾病活动和常见并发症对IBD患者疲劳的影响.
- 为了确定潜在的干预目标来管理IBD疲劳.
- 阐明IBD中疲劳,疾病活动,疼痛,贫血,抑郁,焦虑和生活质量之间的关系.
主要方法:
- 在一所大学诊所对250名IBD患者进行了横截面调查.
- 收集的数据包括关于疲劳,疼痛,焦虑,抑郁和生活质量的验证问卷.
- 使用临床指数 (哈维-布拉德肖,部分梅奥得分) 和生物标志物 (calprotectin,CRP) 评估疾病活性.
主要成果:
- 在189名分析患者中,51.3%的人报告疲劳,12.2%的人经历极度疲劳.
- 多变量分析显示,疲劳与抑郁相关 (p<0.02) 和生活质量下降 (p=0.015).
- 贫血和疾病活动等因素在这个队列中没有显著影响疲劳水平.
结论:
- 疲劳是IBD活跃和不活跃患者的重大负担.
- 治疗考虑因素应该超越炎症和贫血,包括查抑郁症.
- 对于IBD的综合性疲劳管理,建议研究亚临床抑郁症.
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