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在胃肠道恶性瘤中以FAP为目标的PET成像:综合性综述

Ayça Arçay Öztürk¹, Patrick Flamen²

¹Department of Nuclear Medicine, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium. ayca.arcayozturk@hubruxelles.be.

Cancer imaging : the official publication of the International Cancer Imaging Society

|August 23, 2023

概括

在一些胃肠道癌症中,F18-氧葡萄糖正子发射断层扫描/计算机断层扫描 (FDG PET/CT) 有局限性. 纤维细胞激活蛋白 (FAP) 向成像显示了改善瘤检测和管理在这一领域的希望.

科学领域:

在瘤学瘤学.
核医学是一种核医学.
放射化学放射化学是指辐射化学.

背景情况:

F18-fluorodeoxyglucose正子发射断层扫描/计算机断层扫描 (FDG PET/CT) 是一种标准的瘤学成像工具,但在某些胃肠道癌症中存在局限性,原因是痕迹剂吸收或背景活性较低.
纤维细胞激活蛋白 (FAP),一种瘤微环境蛋白,在许多癌症中过度表达,使其成为新型成像和治疗剂的可行标.

研究的目的:

审查FAP向成像在胃肠道瘤学的当前和潜在应用.
为了突出针对特定胃肠道恶性瘤的FAP向标记剂相比FDG PET/CT的优势.

主要方法:

在胃肠道癌症中调查FAP向放射性药物研究的综合文献综述.
对FAP向成像的疗效和局限性进行临床研究数据的分析.

主要成果:

针对FAP的成像显示出在可视化广泛的胃肠道癌症方面具有显著的潜力.
由于肝脏和肠道没有显著的生理性FAP吸收,因此在这些地区,针对FAP的标记剂比FDG PET/CT具有优势.
最近的临床研究表明,针对FAP向的放射性药物在瘤检测和表征方面取得了有希望的结果.

结论:

针对FAP的成像代表了胃肠道瘤学的有希望的进步,有可能克服FDG PET/CT的局限性.
需要进一步的研究和临床验证,以确定FAP向成像作为胃肠道癌症管理的标准模式.

关键词:

与癌症相关的纤维细胞.结肠直肠癌是一种癌症.FAPIAPI FAPIAPI 这是一个很好的方法.在FAPI PET/CT中使用.在FDG PET/CT中使用PET/CT.纤维细胞激活蛋白质的激活蛋白质胃癌胃癌是指胃癌.胃肠道瘤学胃肠道瘤学在这里,PET是PET.

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