治疗慢性辐射直肠炎的口服药物的比较疗效 - - 一项系统性审查
Liangzhe Liu1, Nana Xiao2,3, Jinjun Liang4,5
1Department of Clinical Pharmacy, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China.
口服传统中医药 (TCM) 饮料,网棕酸盐和高纤维饮食对慢性辐射直肠炎 (CRP) 有前途. 需要进一步的研究来证实这些方便的口服治疗对患者的有效性和优化.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 慢性辐射直肠炎 (CRP) 是盆腔放射治疗的衰弱性长期并发症.
- 目前用于CRP的治疗方法对医疗负担很大,这突显了需要可访问的口腔疗法.
研究的目的:
- 系统地审查慢性辐射直肠炎 (CRP) 口服治疗的疗效.
- 评估口服疗法的潜力,作为CRP的有效和方便的管理选择.
主要方法:
- 在2021年2月,在多个数据库 (Cochrane,PubMed,Web of Science,CNKI,VIP) 进行了系统的文献搜索.
- 包括的研究是随机对照试验 (RCT) 和回顾性研究,比较CRP的口服治疗与对照组.
- 主要结局包括直肠出血,腹和症状得分,研究质量使用Cochrane风险偏差工具进行评估.
主要成果:
- 包括十个RCT和一项涉及898名参与者的回顾性研究.
- 与安慰剂相比,口服糖酸盐没有显著差异.
- 传统中医药 (TCM) 饮料,网棕酸盐和高纤维饮食在CRP患者中显著改善了症状.
结论:
- 口服TCM饮料,网棕酸盐和高纤维饮食代表了治疗慢性辐射直肠炎 (CRP) 的有希望的治疗选择.
- 口服pentoxifylline和托科菲罗尔的组合没有产生显著的益处.
- 进一步的大规模,多中心的RCT对于验证这些口腔治疗的疗效和安全性以及完善CRP的管理策略至关重要.
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