在患有肥胖症的儿科人口中预测胰岛素抵抗
Daniela Araújo1,2,3, Carla Morgado4,5,6, Jorge Correia-Pinto2,3,7,8
1From the Pediatrics Department, Hospital de Braga, Braga, Portugal.
Journal of pediatric gastroenterology and nutrition
|August 23, 2023
概括
在肥胖儿童和青少年中早期发现胰岛素抵抗 (IR) 是至关重要的. 使用人口和临床数据的模型,特别是禁食胰岛素,可以准确预测IR风险.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 代谢障碍 代谢障碍 代谢障碍
- 肥胖问题研究研究
背景情况:
- 胰岛素抵抗 (IR) 是肥胖儿童和青少年日益关注的问题,需要早期诊断以预防长期健康问题.
- 识别IR的预测因素对于儿童群体的及时干预和管理至关重要.
研究的目的:
- 确定儿童和青少年胰岛素抵抗 (IR) 的预测因子.
- 开发和验证一个多变量模型,在这个人口群体中准确预测IR.
主要方法:
- 对1423名参与者 (3-17岁) 的人口,临床和生化数据进行了横截面分析.
- 开发和验证了使用不同患者队列的多变量回归模型.
- 用曲线下的面积 (AUC),灵敏度,特异性和负预测值来评估模型性能.
主要成果:
- 使用人口和临床变量的模型显示,IR具有良好的区分能力 (AUC:0.834-0.868).
- 添加禁食胰岛素显著提高了预测能力 (AUC:0.996),经过验证的模型显示出了出色的区分能力 (AUC:0.978).
- 在所有模型中都始终观察到高负预测值,这表明强有力的排除IR的能力.
结论:
- 人口和临床变量有效地识别了中度至高风险的儿童和青少年.
- 对于通过这些预测模型识别的个人,建议对禁食胰岛素进行评估.
- 开发的模型为儿童肥胖的早期IR检测提供了有价值的工具.
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