暴露于微粒物质成分和人类精液质量下降:一个多中心研究
Lingxi Wang1, Ting Xu1, Qiling Wang2,3
1Department of Preventive Medicine, Shantou University Medical College, Shantou 515041, China.
Environmental science & technology
|August 23, 2023
概括
暴露于细颗粒物 (PM2.5) 空气污染会对精子质量产生负面影响,包括精子数量和运动性. 化物和酸盐等特定的PM2.5化学成分与精子数量的减少有关,强调减少空气污染的必要性.
科学领域:
- 环境健康 环境健康
- 生殖毒理学 生殖毒理学
- 流行病学 流行病学
背景情况:
- 暴露于细颗粒物 (PM2.5) 对公众健康的担忧越来越大.
- 关于PM2.5化学成分对人类精子质量的具体影响的研究有限.
- 了解这些关联对于进行生殖健康评估至关重要.
研究的目的:
- 调查暴露于PM2.5化学成分和人类精子质量下降之间的关系.
- 探索PM2.5暴露和精液参数之间的剂量反应关系.
- 为了确定影响精子质量的特定PM2.5成分.
主要方法:
- 一项基于多中心人口的队列研究,涉及来自33,234名捐赠者的78,952个精液样本 (2014-2020年).
- 使用深度学习模型估计的每日PM2.5化学成分暴露,分辨率为1公里.
- 用于分析对精液质量和暴露-反应关系的影响的线性混合模型.
主要成果:
- 增加的PM2.5暴露与精子度降低,渐进性运动性和总运动性显著相关.
- 化物 (Cl-) 和酸盐 (NO3-) 暴露与精子数量减少有关.
- (NH4+) 暴露显著与逐渐降低的精子运动性有关.
结论:
- 暴露于PM2.5化学成分会对人类精子质量产生不利影响.
- 像Cl-,NO3-和NH4+这样的特定成分对精子参数表现出有害影响.
- 迫切需要减少PM2.5空气污染,以保护男性生殖健康.
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