乌干达结核病儿童死亡率的预测因素,2016-2021年
G L Becker1, P Amuge2, R Ssebunya2
1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
概括
在乌干达,儿童结核病 (TB) 治疗的死亡率很高. 营养不良和艾滋病毒感染显著增加了接受结核病治疗的儿童死亡的风险.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 儿科 儿科 儿科
背景情况:
- 在乌干达,儿科结核病 (TB) 的高负担.
- 需要确定影响结核病治疗儿童死亡率的因素.
研究的目的:
- 评估乌干达儿童结核病治疗期间死亡率的预测因素.
- 分析城市和农村转诊医院的儿科患者结核病治疗结果.
主要方法:
- 历史队列研究设计.
- 包括从2016年至2021年的儿科结核病例 (<15岁).
- 卡普兰-梅尔生存分析和多变量考克斯回归模型.
主要成果:
- 确定了1658例儿科结核病例;治疗期间死亡率为7.8%.
- 死亡的中位时间是治疗开始后的27天.
- 艾滋病毒,中度和重度营养不良是死亡率的重要预测因素.
结论:
- 在乌干达的儿科结核病患者中观察到高死亡率.
- 营养不良和艾滋病毒是结核病治疗期间死亡的关键风险因素.
- 死亡主要发生在结核病治疗的密集阶段.
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