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在CLSA中口腔和认知健康指标的集群分析:对胆固醇活性作为链接的探索性研究

K Rohani¹, B Nicolau¹, S Madathil¹

¹Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, Canada.

JDR clinical and translational research

|August 23, 2023

概括

糟糕的口腔健康与认知能力下降有关,但机制尚不清楚. 这项研究没有发现证据表明骨矿物质密度 (BMD) 解释了加拿大人的这种联系,这表明其他因素可能参与其中.

科学领域:

老年学与公共卫生
神经科学和口腔健康研究研究

背景情况:

糟糕的口腔健康是认知能力下降的潜在风险因素,但潜在的生物机制尚未得到充分理解.
胆固醇系统与认知功能有关,骨矿物质密度 (BMD) 已被提出作为其活性的代理.

研究的目的:

在中年到老年加拿大人中确定不同的口腔和认知健康模式.
确定 BMD 是否作为胆固醇神经元活动的代理,解释了观察到的口腔和认知健康群.

主要方法:

从25444名加拿大长度老龄化研究 (CLSA) 参与者的基线数据进行横截面分析.
潜在类分析以基于自我报告的口腔健康和7个认知测试来识别口腔和认知健康集群.
多变量后勤回归以评估骨损伤和集群成员之间的关联,调整共变量.

主要成果:

确定了五个口腔健康和四个认知健康集群.
增加的BMD与更好的口腔健康集群 (OR=1.58,95% CI:0.85-2.92) 或认知健康集群 (OR=1.61,95% CI:1-2.6) 并没有显著关联.

结论:

加拿大老年人有不同的口腔和认知健康状况,受假牙使用等因素的影响.
骨矿物质密度似乎没有通过胆固醇通路调解口腔健康和认知健康之间的关系.

关键词:

这就是CLSA CLSA.衰老的衰老衰老的衰老骨密度骨密度骨密度胆固醇神经元是一种神经元.认知认知认知口腔疾病口腔疾病口腔健康是指口腔的健康状况.

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